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Utilized sciences for manufacturing therapeutic monoclonal antibodies have matured inside the a few years given that first remedy was accredited, nevertheless there are nonetheless workflow challenges that ought to be addressed. Producing these biologics requires fixed and repeatable processes. Nonetheless, an important step—tangential flow into filtration (TFF)—stays an mandatory provide of variability. Normal TFF strategies that depend upon cassette holders and torque-based arrange are prone to setup inconsistencies which will impact yield and in the reduction of reproducibility. Newer designs deal with these factors, serving to producers work additional successfully and continually.
On this GEN webinar, Mark Perreault will give attention to strategies for bettering mAb manufacturing using the newest utilized sciences for separating, purifying, and concentrating therapeutic biomolecules. He’ll present case analysis that illustrate a model new flat-sheet holder-less TFF design for multi-use workflows along with data demonstrating some great benefits of the design, along with decreased operator errors and shorter setup time. You’ll moreover learn how the updated design removes the need for cassette holders and permits uniform flow into distribution all through the membrane ground whereas minimizing torquing and product loss.
Key takeaways embrace:
• How a holder-less design improves course of reliability by eliminating arrange factors and decreasing operational complexity.
• How the design affords seamless scalability, as a result of the gadget maintains fixed channel path lengths and stress drop profiles all through cassette codecs.
• How uniform flow into distribution enhances product yield and reduces variability in effectivity.
• How separation effectivity, flux costs, and fouling resistance of holder-less designs consider to standard cassettes.
A reside Q&A session will adjust to the exhibits, offering you a chance to pose inquiries to our skilled panelists.
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